I don't think so, for the reasons above.
If someone is out cold, administering opioids would generally be contraindicated, especially after a head on.
Too much possibility of TBI.
No way to assess with Glasgow Scale or Ranchos Los Amigos scale accurately if the patient has been sedated or medicated in a way that would interfere with the assessment. With that fireball, serious burns are a definite possibility, too.