Not in anything less than an ocean rigged craft. We fish here in a 16 ft. Lund with an 80 horse motor, and when the wind rips down the lake at 15 or better (long fetch) it's too rough to be out there.
I'm on the Flathead. It's big enough to be serious, and small enough to have a close chop. It's a nasty lake in hard wind. It does weird stuff too - closer to what a big river does. Superior though... You can just disappear.