Common Dandelion blocks spike protein: study

[Elderberry]

bioRxiv by Hoai Thi Thu Tran, Nguyen Phan Khoi Le, Michael Gigl, Corinna Dawid, Evelyn Lamy March 19, 2021

Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro

Abstract

On 11th March 2020, coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, was declared as a global pandemic by the World Health Organization (WHO). To date, there are rapidly spreading new “variants of concern” of SARS-CoV-2, the United Kingdom (B.1.1.7), the South African (B.1.351) or Brasilian (P.1) variant. All of them contain multiple mutations in the ACE2 receptor recognition site of the spike protein, compared to the original Wuhan sequence, which is of great concern, because of their potential for immune escape. Here we report on the efficacy of common dandelion (Taraxacum officinale) to block protein-protein interaction of spike S1 to the human ACE2 cell surface receptor. This could be shown for the original spike D614, but also for its mutant forms (D614G, N501Y, and mix of K417N, E484K, N501Y) in human HEK293-hACE2 kidney and A549-hACE2-TMPRSS2 lung cells. High molecular weight compounds in the water-based extract account for this effect. Infection of the lung cells using SARS-CoV-2 spike pseudotyped lentivirus particles was efficiently prevented by the extract and so was virus-triggered pro-inflammatory interleukin 6 secretion. Modern herbal monographs consider the usage of this medicinal plant as safe. Thus, the in vitro results reported here should encourage further research on the clinical relevance and applicability of the extract as prevention strategy for SARS-CoV-2 infection.

Significance statement

SARS-CoV-2 is steadily mutating during continuous transmission among humans. This might eventually lead the virus into evading existing therapeutic and prophylactic approaches aimed at the viral spike. We found effective inhibition of protein-protein interaction between the human virus cell entry receptor ACE2 and SARS-CoV-2 spike, including five relevant mutations, by water-based common dandelion (Taraxacum officinale) extracts. This was shown in vitro using human kidney (HEK293) and lung (A549) cells, overexpressing the ACE2 and ACE2/TMPRSS2 protein, respectively. Infection of the lung cells using SARS-CoV-2 pseudotyped lentivirus was efficiently prevented by the extract. The results deserve more in-depth analysis of dandelions’ effectiveness in SARS-CoV-2 prevention and now require confirmatory clinical evidence.

More: https://www.biorxiv.org/content/10.1101/2021.03.19.435959v1.full

[catfish1957]

Fauxci will start proposing applying round up ASAP, to stem of this level of mass- dis-information.   

[Elderberry]

Common Dandelion Blocks S Protein Binding to ACE2 Receptors

Deep Roots at Home By Jacqueline 1/19/2022

https://deeprootsathome.com/common-dandelion-blocks-s-protein-binding-to-ace2-receptors/

A groundbreaking Science Direct study just released found that the common dandelion (T. officinale) synthesizes a natural medicine that blocks protein to protein interaction of spike S1 to the human ACE2 cell surface receptor… [with] no or few side effects…” “…including rapidly spreading new “variants of concern” of SARS-CoV-2…”

This means infection of the lung cells using SARS-CoV-2 was efficiently prevented by anti-covid phytochemicals in a water-based dandelion extract (basically as tea or a tincture).

It also means that dandelion tea, safe for use in pregnancy, could prevent miscarriage by blocking the spike protein from cross-reacting against syncitin, which is vital in pregnancy.

Dandelion leaves can be easily and quickly transformed into natural medicine through the simple use of an ultrasonic cleaner. In a video below, it shows how to use an ultrasonic cleaner to extract medicinal components from rosemary herb. The exact same process can be used with dandelion leaves to make your own anti-spike protein herbal extract medicine.

We know pine trees, star anise, and fennel seeds are easy to obtain from nature, but dandelions literally grow like weeds!

Importantly, when making natural medicine from herbs, you pay nothing to a pharmacy, need no permission from an insurance company, need no authorization from a doctor, and you don’t even need the FDA.

[Kamaji]

Ray Bradbury's book, Dandelion Wine, will soon be listed by DHS as domestic terrorism literature.

[Wingnut]

Dandelion leaf salad is great. 

[roamer_1]

HAHAHAHAHA! Dandelion leaves are always in my salads. If anyone needs to know how to make Dandelion root coffee, give me a ping.

What is this? I have been dosing all the way along.