Another interesting, counterintuitive, idea. Sort of like using botulin toxin for migraines (and face wrinkles).
Deadly anthrax toxin blocks multiple types of pain in mice, study shows
Date: December 20, 2021
Source: Harvard Medical School
Summary:
A new study shows that a toxin from the microbe that causes anthrax can silence multiple types of pain in mice. Researchers found the toxin targets pain-sensing cells to alter signaling and block pain. Building on that finding, researchers engineered an anthrax protein vehicle to deliver different types of treatments into pain receptors and modulate nerve-cell function. The findings can inform the design of therapies that selectively target pain-sensing fibers without the widespread systemic effects of opioids and other pain killers.
Source:
https://www.sciencedaily.com/releases/2021/12/211220120629.htm