For the same reason expressed here:
The study has been widely characterised as misleading, according to Brazilian factchecking site Estadão Verifica because it heavily emphasised ivermectin in its results, though that drug was one of three included in the kit and was only taken over a period of two days.
The tests of Hydroxychloroquine and Ivermectin have been misleading, too. Hydroxychloroquine use was initially proposed as ONE PART of a
three part regimen, in this case with Azithromycin and Zinc supplementation. Similarly, Ivermectin use was proposed as ONE PART of a three part regimen, in concert with doxycycline and Zinc supplementation.
Test one part and you have cut two legs off a three legged stool and then say it fails to work as a seat.
Why a three part regimen?
Hydroxychloroquine and Ivermectin act as ionophores (there are other substances which do this also) which act to admit Zinc ions into the Type 1 Pneumocytes that the virus affects. The Type 1 Pneumocytes are the lung cells which perform the exchange of Oxygen and CO2 with the bloodstream. Those are the cells the SARS-CoV-2 lab-engineered virus targets, and that was noted in the scientific journal
Nature paper in which the chimera was announced (in 2015, just after the research had been moved from North Carolina to Wuhan).
When the virus uses the spike protein to gain access to the cell at the ACE2 receptor site, it injects its RNA into the cell. Ordinarily, there is little to no zinc in those cells, only a tiny fraction of what the average person gets in their diet, primarily from red meat (what the FDA has been telling us for years we are supposed to eat little of).
IF there is no zinc present, the virus hijacks the proteins in the cell and replicates, eventually destroying the cell and setting off the body's cleanup system.
I won't go into that, but if that system goes into overdrive, the body experiences a Cytokine Storm, where the immune system attacks healthy cells, and most likely the patient will die.
In the process of destroying Type 1 Pneumocytes and replicating, the virus leaves the patient with fewer sites to exchange oxygen and CO2 with the blood stream, and the patient becomes "short of breath" (hypoxic, if this goes unchecked).
IF, however, enough zinc
is present in the Type 1 Pneumocytes, it interferes with the ability of the virus to replicate. This is a well documented phenomenon, and was noted with SARS. It is also the reason, incidentally, that most cold and flu remedies contain zinc. (Some flavonoids also act as ionophores.)
The ionophore acts as a transport mechanism to get the zinc in. Without those two legs of the stool (one being zinc supplementation), the only zinc that the body has to work with is what it has scrounged from the patient's diet, and often, the treatment is doomed to failure. This is why testing just the ionophore without the Zinc is not indicative of the potential of these antiparasitic drugs to stop the virus, because they are being tested alone.
The third leg of the stool is an antibiotic, ideally a Macrolide antibiotic like azithromycin or Erythromycin which also (idiopathically) helps to regulate the immune system and keep it from going into overdrive and attacking healthy cells (the reason so many early victims had diffuse blood clots in their lungs). There is also the benefit of fighting or prophylaxis against opportunistic bacterial infections.
All three and you have a winner. just one, and you likely don't. I have taken Ivermectin and zinc and got well in four days.
The ideal time to administer this regimen is at the earliest sign of symptoms, when the virus can be stopped from replicating and damaging cells most effectively. Delay increases viral load, and that viral load comes at the cost of Type 1 Pneumocytes, and, ultimately, the patient's ability to breathe.
Many of the studies which showed the drugs (HCQ and Ivermectin) to be failures are crafted, and have been from the start, for the drugs to do just that: fail.
The drugs were administered to hospitalized moderate to late stage patients, whose lungs were already damaged severely, without the macrolide antibiotic or zinc, which are essential to the therapy and preventing severe cytokine reactions, well after the damage was done.
In some cases, the amounts of the drugs administered were toxic, and in one study in Brazil, the LD50 (of Chloroquine) was exceeded for patients by a factor exceeding three. Naturally, patients died. Only a normal clinical dose was needed to act as an ionophore.
Early on, I pointed out the basic problems in these studies, and the fact that
not one of them administered the critical zinc supplementation. If the patients did not have a diet high in red meat, or for vegans, high in beans and legumes, seeds, nuts, oatmeal, tofu, or spinach, chances are their outcome was below optimal.
Now, think about hospital food, for the patient who has been there a few days, and the odds of survival go down.
