If there is going to be gain-of-function research, locate the laboratory on a remote island in the middle of the ocean, like Ascension Island or St Helena Island, not in the middle of a densely populated urban metropolis.
There is no need to perform gain-of-function research. Mother Nature is already working on it.
The next time some bat virus research scientists want to gather bat feces and urine samples from a cave, light that cave up with napalm.