You have to wonder if wanting to run out the clock on her seat is affecting her treatment decisions, e.g. no higher-risk surgery even if it might improve her long-term prospects?
True. Many people were begging John McCain to step down, take care of himself, be with his family, and make final arrangements. He refused and continued 'working', such as that is with his job. I believe his obsession to keep his Senate seat, and his refusal to convalesce and rest, likely hastened his death.
For some people with a certain mentality their job, their position, is their whole life. Stepping down for this kind of person, is the same as death in their world.