Investigators determined that by limiting an amino acid called asparagine, it could reduce the ability of the cancer to travel to distant sites in the body.
A protein building block found in asparagus and other foods may hold a key to preventing the spread of an often-deadly type of breast cancer, according to Cedars-Sinai scientists in a new study published Wednesday.
Investigators determined that by limiting an amino acid called asparagine in laboratory mice with triple-negative breast cancer, they could reduce the ability of the cancer to travel to distant sites in the body. Among other techniques, the team used dietary restrictions to limit asparagine. Foods rich in asparagine include dairy, whey, beef, poultry, eggs, fish, seafood, asparagus, potatoes, legumes, nuts, seeds, soy and whole grains.
Foods low in asparagine include most fruits and vegetables, according to the multi-center study published in the medical journal Nature.
"Our study adds to a growing body of evidence that suggests diet can influence the course of the disease,'' said Dr. Simon Knott, associate director of the Center for Bioinformatics and Functional Genomics at Cedars-Sinai and one of two first authors of the study.
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Asparagine bioavailability governs metastasis in a model of breast cancer
https://www.nature.com/articles/nature25465
