No way she will resign. People like Pelosi, McCain, Schumer, Feinstein, Waters, et al, cannot live without their office. Asking one of these obsessive fanatics to resign is like asking them to cut off a leg. Their office is part of their soul, and they will never leave office willingly. We will have to pull them away from their desks by force, unless they die. And even that is no guarantee.
We can see from McCain that now the Senate wants to become the American "House of Lords". So they can designate someone they control to replace them after they resign or die.