The biggest shake up will be when Ginsburg retires, provided that Trump sticks to the original list of conservative justice choices.
Trump White House Is Getting Things Ready For A Second SCOTUS Vacancy...."Now, should a second vacancy occur, a) Republicans will not have as much trouble to confirm this person; and b) the composition of the Court could become more decidedly conservative. This is why it was probably best for the Democrats to keep their powder dry, but we’ve crossed that bridge. Even right now, the Trump White House is preparing to set the groundwork for that second vacancy and to fill as many as 100 vacancies in the federal court system.
The rumor is that Justice Anthony Kennedy is set to retire shortly and that Gorsuch’s confirmation would be the signal that his seat would be in good hands. Apparently, both Trump and Kennedy’s children are creating this back channel of communication, as Don. Jr. and Kennedy’s son, Justin, know each other....
.....The White House has also closely monitored retirement chatter by tapping into the network of former Kennedy clerks, a group that includes Gorsuch himself. Some in the legal world viewed Gorsuch’s selection — he would be the first Supreme Court clerk to serve alongside a former boss — as an olive branch to Kennedy that, should he retire next, his seat would be in reliable presidential hands....
... White House officials have already set in motion plans to fill the more than 100 lower court vacancies, including more than 10 percent of the crucial seats on various U.S. Courts of Appeals, in a bid to tug America’s courts in a more conservative direction for decades to come...
...Trump took the unusual step on the campaign of producing a public list of 21 possible candidates for the Supreme Court. That pool of judicial talent — in particular, younger judges serving on state supreme courts — are now the front-runners to fill top federal court vacancies, according to three people involved in Trump’s judge-selection process....
https://townhall.com/tipsheet/mattvespa/2017/04/07/politico-trump-white-house-is-getting-things-ready-for-a-second-scotus-vacancy-n2310065