Scientists find ‘master regulator’ that could reverse brain aging

[Kamaji]

Scientists find ‘master regulator’ that could reverse brain aging

Date:    January 18, 2026
Source:    University of New Mexico Health Sciences Center
Summary:
    Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The findings challenge long-held assumptions about tau’s necessity and highlight a promising new path for fighting Alzheimer’s and brain aging. Scientists now believe OTULIN may act as a master switch for inflammation and age-related brain decline.

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Source:  https://www.sciencedaily.com/releases/2026/01/260116035348.htm