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Chinese Scientists Create Mutant COVID Strain That is 100% Lethal in Mice and Targets Brain

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libertybele:
 :bkmk:

mountaineer:
 Chinese lab crafts mutant COVID-19 strain with 100% kill rate in ‘humanized’ mice: ‘Surprisingly’ rapid death
By Social Links for Katherine Donlevy
Published Jan. 16, 2024
Updated Jan. 17, 2024, 7:26 a.m. ET
NY Post
--- Quote ---In a Wuhan-esque study, Chinese scientists are experimenting with a mutant COVID-19 strain that is 100% lethal to “humanized” mice.

The deadly virus — known as GX_P2V — attacked the brains of mice that were engineered to reflect genetic makeup similar to people, according to a study shared last week out of Beijing.

“This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses,” the authors wrote.

The deadly virus is a mutated version of GX/2017, a coronavirus cousin that was reportedly discovered in Malaysian pangolins in 2017 — three years before the pandemic. Pangolins, also called scaly anteaters, are mammals found in warm areas of the planet. ...
--- End quote ---

mountaineer:
What is the “Disease X Act”?

--- End quote ---

https://twitter.com/LegendaryEnergy/status/1747721316755701997

DefiantMassRINO:
1.) The closest natural phylogenetic relatives have been found in bats in Laos.
2.) The Chi-coms are still working to backfill their pangolin wet market lie by genetically engineering a chimeric virus that did not exist at the time of the Covid-19/SARS2 outbreak in Wuhan (Fall, 2019).

The Chinese Communist Party owes the World reparations for a lab leak of Covid-19/SARS2.  The Chi-coms owe pangolins an apology for besmirching their reputation.

Bedtime reading for insomniacs:

https://www.nature.com/articles/s41421-023-00581-9

Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Abstract

The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related coronaviruses (SC2r-CoV) and the genome of BANAL-20-52 shares the highest homology with SARS-CoV-2. However, the risk of their potential zoonotic transmission has not been fully evaluated. Here, we determined their potential host susceptibility among 13 different bat species and 26 different animal species, and found that both might have extensive host ranges, indicating high zoonotic transmission potential. We also determined the cryo-EM structures of BANAL-20-52 and BANAL-20-236 S proteins at pH 5.5 and the complex of BANAL-20-236 S1 and Rhinolophus affinis ACE2, and found that both trimeric S proteins adopt all three receptor binding domains (RBDs) in “closed” conformation and are more compact than SARS-CoV-2. Strikingly, the unique sugar moiety at N370 of bat SC2r-CoVs acts like a “bolt” and crosses over two neighboring subunits, facilitating the S proteins in the locked conformation and underpinning the architecture stability. Removal of the glycosylation at N370 by a T372A substitution substantially enhances virus infectivity but becomes highly sensitive to trypsin digestion at pH 5.5, a condition roughly mimicking the insectivorous bat’s stomach digestion. In contrast, WT S proteins of SC2r-CoVs showed considerable resistance to trypsin digestion at pH 5.5, indicating that the highly conserved T372 in bat CoVs might result from the selective advantages in stability during the fecal-oral transmission over A372. Moreover, the results of cross-immunogenicity among S proteins of SARS-CoV-2, BANAL-20-52, and BANAL-20-236 showed that A372 pseudoviruses are more sensitive to anti-S sera than T372, indicating that immune evasion might also play a role in the natural selection of T372 over A372 during evolution. Finally, residues 493 and 498 of the S protein affect host susceptibility, and residue 498 also influences the immunogenicity of the S protein. Together, our findings aid a better understanding of the molecular basis of CoV entry, selective evolution, and immunogenicity and highlight the importance of surveillance of susceptible hosts of these viruses to prevent potential outbreaks. ...

Smokin Joe:

--- Quote from: Free Vulcan on January 18, 2024, 05:17:06 am ---You ain't jokin'. As much as this virus mutates, there's no way to vax anyone for any amount of time. It will burn thru the urban pop like wildfire and require almost permanent extreme isolative quarantine. Like on an island several miles of the coast, no way in or out, sink anything that approaches.

What do these psychos think they are doing?

--- End quote ---
Biological warfare. It's just a question of when. Taiwan could be the where.

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