I’ve listened to her interviews since she’s left the White House, and it seems that she was happy to leave and both of them admitted that it was a strain on their marriage
After all that, where is there any indication that she wants to run for president?
First things first. The way I think things will go is Biden will finally step down leaving Harris in place. Harris will likely pick Michelle as her running mate. Once Harris is sworn in she, will for certain reason need to step down and Michell will then become president. Barrack & Co. have been running things from the sidelines all along. Obviously Barrack can't run again, but he can instruct Michelle. Michelle was a very popular First Lady among the millennial, progressives, liberals and Blacks. Barrack wants another two terms.
This is strictly based on observations, global events and my own (precognitive) gut feeling; certainly you can take this with a grain of salt.
Any bets as to who would win should it be a Trump v. Harris and Michelle election???
If not Michell than either Valerie Jarett or Susan Rice -- same outcome. Barrack will still be leading by the sidelines.