Author Topic: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain  (Read 726 times)

0 Members and 1 Guest are viewing this topic.

Offline Elderberry

  • TBR Contributor
  • *****
  • Posts: 24,280
Legal Insurrection  by Leslie Eastman Friday, November 18, 2022

More good news: Drug overdose deaths may finally be plateauing across nation for first time since start of Covid pandemic.

A team of researchers at the University of Houston announced a vaccine that could block fentanyl from entering the brain and stops users from getting high. The vaccine is being hailed as a “game changer” in the battle against the opioid overdose epidemic.

    In testing on rats, the vaccine “produced significant amounts” of anti-fentanyl antibodies that clung to the deadly addictive synthetic opioid, according to a study printed in the journal Pharmaceutics.

    That prevented the drug “from entering the brain, allowing it to be eliminated out of the body via the kidneys,” said lead author Colin Haile of the University of Houston’s Drug Discovery Institute.

The drug is described as a vaccine, as it will create antibodies to target fentanyl and prevent it from entering the brain.

More: https://legalinsurrection.com/2022/11/scientists-create-vaccine-blocking-fentanyl-from-entering-the-brain/


https://www.youtube.com/watch?v=2nCQbnDYXa4

Offline Kamaji

  • Hero Member
  • *****
  • Posts: 57,889
Re: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain
« Reply #1 on: November 18, 2022, 10:42:21 pm »
We shall see ....

Offline Hoodat

  • Hero Member
  • *****
  • Posts: 35,818
Scientists Create Vaccine Against Effects of Fentanyl, Human Trials Begin in 2023

Joshua Young  |  11/18/2022


Scientists at the University of Houston have created a vaccine that could block the "euphoric effects" of the drug fentanyl in an effort to reduce the destructive effects of the opioid, as fentanyl overdoses cause almost 200 Americans to die per day.

A professor of psychology at the Texas college and the lead researcher on the project, Dr. Colin Haile, told the Daily Mail, "When an individual gets the vaccine, they get antibodies against fentanyl. The antibodies will bind to the drug and keep it from getting to the brain. If you prevent fentanyl from entering the brain you prevent it from producing euphoric effects and effects that lead to overdose deaths."

Testing was performed on a group 60 lab rats, 28 of whom were given shots of the vaccine. After three doses, the rats were given fentanyl. Two experiments were performed and the vaccinated rats reacted to pain while the unvaccinated rats, ostensibly high on fentanyl, did not react to the pain.

The researchers concluded that the vaccine is effective in blocking the euphoric high that accompanies the drug's use by preventing its chemical binding in the brain. The researches believe they can begin human trials in 2023.  .  .  .

https://www.humanevents.com/2022/11/18/scientists-create-vaccine-against-effects-of-fentanyl-human-trials-begin-in-2023



So first, they invent SARS-2 in a lab and release it to the world in order to market a 'vaccine' that masks it.  Now they're letting fentanyl into the country in order to market a 'vaccine' that masks it.

These people are monsters.
If a political party does not have its foundation in the determination to advance a cause that is right and that is moral, then it is not a political party; it is merely a conspiracy to seize power.

-Dwight Eisenhower-


"The [U.S.] Constitution is a limitation on the government, not on private individuals ... it does not prescribe the conduct of private individuals, only the conduct of the government ... it is not a charter for government power, but a charter of the citizen's protection against the government."

-Ayn Rand-

Offline jmyrlefuller

  • J. Myrle Fuller
  • Cat Mod
  • *****
  • Posts: 22,326
  • Gender: Male
  • Realistic nihilist
    • Fullervision
Fentanyl is a chemical, not a pathogen —there is no such thing as "fentanyl antibodies."

This has to be a prank on the journal.
New profile picture in honor of Public Domain Day 2024

Offline jmyrlefuller

  • J. Myrle Fuller
  • Cat Mod
  • *****
  • Posts: 22,326
  • Gender: Male
  • Realistic nihilist
    • Fullervision
Re: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain
« Reply #4 on: November 19, 2022, 03:50:58 am »
As I noted in another thread on the topic, this looks like a prank on the journal that published it.1, one of the authors of the study is a psychology professor, and 2, there is no such thing as "fentanyl antibodies" because fentanyl is not a pathogen; it's a chemical.
New profile picture in honor of Public Domain Day 2024

Offline Hoodat

  • Hero Member
  • *****
  • Posts: 35,818
It could be some type of enzyme that the cells have been reprogrammed to generate that acts on the fentanyl molecule.
If a political party does not have its foundation in the determination to advance a cause that is right and that is moral, then it is not a political party; it is merely a conspiracy to seize power.

-Dwight Eisenhower-


"The [U.S.] Constitution is a limitation on the government, not on private individuals ... it does not prescribe the conduct of private individuals, only the conduct of the government ... it is not a charter for government power, but a charter of the citizen's protection against the government."

-Ayn Rand-

Online Free Vulcan

  • Technical
  • *****
  • Posts: 23,686
  • Gender: Male
  • Ah, the air is so much fresher here...
People don't generally take fentanyl for fentanyl, it's usually slipped in something else like a mickey to boost it's effect, and it will still be just as toxic especially in pure form.
« Last Edit: November 19, 2022, 04:27:49 am by Free Vulcan »
The Republic is lost.

Offline MOD8

  • Hero Member
  • *****
  • Posts: 376
Re: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain
« Reply #7 on: November 19, 2022, 04:32:14 am »
Topics merged.

Offline Elderberry

  • TBR Contributor
  • *****
  • Posts: 24,280
Re: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain
« Reply #8 on: November 19, 2022, 01:04:40 pm »
 An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

by Colin N. Haile,  Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L.,  Duddupudi,  Gregory D. Cuny , Elizabeth B. Norton, Thomas R. Kosten, and Therese A. Kosten


Department of Psychology & TIMES, University of Houston, Houston, TX 77204, USA

Department of Pharmacological & Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA

Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA

Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA

The Michael E DeBakey Veteran’s Affairs Medical Center, Houston, TX 77030, USA


 Academic Editor: Teijo Saari
Pharmaceutics 2022, 14(11), 2290; https://doi.org/10.3390/pharmaceutics14112290
Received: 31 August 2022 / Revised: 13 October 2022 / Accepted: 18 October 2022 / Published: 26 October 2022

Abstract

Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and confirm our previous study in mice showing immunological and antinociception efficacy of our FEN vaccine administered with the adjuvant dmLT. In this study, immunized male and female rats produced significant levels of anti-FEN antibodies that were highly effective at neutralizing FEN–induced antinociception in the tail flick assay and hot plate assays. The vaccine also decreased FEN brain levels following drug administration. Immunization blocked FEN-induced, but not morphine-induced, rate-disrupting effects on schedule-controlled responding. Vaccination prevented decreases on physiological measures (oxygen saturation, heart rate) and reduction in overall activity following FEN administration in male rats. The impact of FEN on these measures was greater in unvaccinated male rats compared to unvaccinated female rats. Cross-reactivity assays showed anti-FEN antibodies bound to FEN and sufentanil but not to morphine, methadone, buprenorphine, or oxycodone. These data support further clinical development of this vaccine to address OUD in humans.

 3. Results
3.1. Anti-FEN Antibody Levels
Anti-FEN IgG antibody levels over ten weeks are shown in Figure 1B. ANOVA yielded significant main effects for Sex (F(1, 28) = 8.604, p < 0.01) and Time (F(3, 84) = 13.85, p < 0.0001) and a significant Sex X Time interaction (F(3, 84) = 10.37, p < 0.0001). For male rats, post hoc multiple comparisons revealed significant differences in anti-FEN IgG antibody levels between 4 and 6 (p < 0.01), 8 (p < 0.01), and 10 (p < 0.05) weeks. For female rats, post hoc multiple comparisons revealed a significant difference in antibody levels between weeks 4 and 6 (p < 0.05). Between group comparisons revealed a highly significant difference in antibody concentrations for male rats compared to female rats at weeks 8 (p < 0.0001) and 10 (p < 0.01). Overall, anti-FEN IgG antibody levels increased over time compared to baseline in male rats and were greater than levels in female rats.

 3.3. Fentanyl Brain Levels
Figure 2E and Figure 3E show brain levels of FEN following a high dose administration. ANOVA revealed significant main effects for Vaccine status (F(1, 54) = 599.90, p < 0.001) and Sex (F(1, 54) = 10.70, p < 0.005) and their interaction (F(1, 54) = 4.53, p < 0.05). Post hoc multiple comparisons revealed significant differences between vaccine groups of both sexes (p’s < 0.01–0.0001). As expected, greater amounts of FEN were present in the brains of unvaccinated male and female rats compared to vaccinated rats of either sex. Interestingly, female unvaccinated rats had higher brain FEN levels compared to male unvaccinated rats (p < 0.01).

 4. Discussion
The present study expands upon our previous results by further characterizing our anti-FEN vaccine in male and female Sprague Dawley rats. We find that the FEN-CRM+dmLT vaccine: (1) produces anti-FEN antibodies that are long-lasting; (2) blocks FEN-induced nociception in the tail flick and hotplate assays; (3) leads to lower FEN brain levels following FEN administration 20-weeks after initial vaccination; (4) blocks the rate-disrupting effects of FEN, but not MOR, on schedule-controlled responding; (5) protects against FEN-induced decreases in oxygen saturation, heart rate, and activity levels in male rats and decreases in heart rate in female rats; and (6) generates anti-FEN antibodies that bind specifically to FEN and not to other opioids. Additionally, we report on several sex differences in response to the vaccine or to FEN. These findings include: (1) greater anti-FEN antibody levels in male rats compared to female rats across weeks; (2) a more pronounced FEN-induced antinociception in male rats in the tail flick test; (3) greater penetration of FEN into the brain in female rats; and (4) greater FEN-induced decreases on oxygen saturation and heart rate in male rats compared to female rats. These data show our FEN-CRM conjugate vaccine coupled with the adjuvant dmLT can produce anti-FEN antibodies that eliminate the behavioral and physiological effects of FEN. The vaccine formulation includes CRM197, a carrier protein in vaccines already FDA-approved, and GMP-grade dmLT, that has proven safe and effective in many clinical trials [45]. This is the first report to show the effectiveness of this vaccine formulation in male and female rats that extend our previous findings in mice [26] and are consistent with other vaccine studies targeting opioids [22,23,24,25,42,46,47].

Complete Article: https://www.mdpi.com/1999-4923/14/11/2290/htm

Offline Kamaji

  • Hero Member
  • *****
  • Posts: 57,889
Re: Scientists Create Vaccine Blocking Fentanyl From Entering the Brain
« Reply #9 on: November 20, 2022, 06:46:35 pm »
Fentanyl is a chemical, not a pathogen —there is no such thing as "fentanyl antibodies."

This has to be a prank on the journal.

Antibodies aren't limited to "pathogens".  https://en.wikipedia.org/wiki/Antibody