Just recently here at Eglin an F-16 successfully shot a Cruse missile (drone) out of the sky using an AGR-20A Advanced Precision Kill Weapon System laser-guided rocket.
Originally, the AGR-20A was developed as a low cost, low collateral damage air-to-ground weapon for use in Afghanistan and Iraq; adapting the system for counter-air use is momentous. The AGR-20A is a fraction of the cost of the AIM-120 missile, commonly used for cruise missile defense. Additionally, the AGR-20A can be loaded faster than an AIM-120 and an aircraft can carry two-to-three times the number weapons.