Between the mid 1700s and shortly after the war of 1812, the Cherokee and Powhatan nations were as westernized as any British city. They had full blown colonial cities, representatives in colonial government, schools, and even a university. Andrew Jackson basically stole all their land, that prior presidents had recognized, and stripped them of any rights they had. He sent in the army and forcibly removed them from their homes (not tee-pees but some very stately colonial homes that in some cases, later became plantation homes.) If you see old paintings, many were as westernized as George Washington himself. My ancestry is Potawatomi, and you can see old paintings of them and they looked downright Scottish in some images (one of the chiefs in a late 1700s painting I saw, looked kind of like Patrick Stewart with hair.)
Small world... I have Cherokee and Potawatomi blood running in me.... Though long ago and far away.
Go back further than that - The Iroquois nation has a serious Celtic strain in them going way, way back. White with red or blonde hair is common there too... And both the Iroquois and Cherokee nations had systems of law and justice, language and math, money... All the hallmarks of civilization were in them long before the 'white man' ever got here.
I have long been a proponent of a very diverse trade between Europe and the Americas, and between the East and the Americas pretty much all the way along - Shoot, there are Sumerian artifacts among the Inca/Maya for Pete's sake.