Aberrant telomere length and mitochondrial DNA copy number in suicide completers

[Suppressed]

https://www.nature.com/articles/s41598-017-03599-8


Aberrant telomere length and mitochondrial DNA copy number in suicide completers
Ikuo Otsuka, Takeshi Izumi, Shuken Boku, Atsushi Kimura, Yuan Zhang, Kentaro Mouri, Satoshi Okazaki, Kyoichi Shiroiwa, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora & Akitoyo Hishimoto
Scientific Reports 7, Article number: 3176 (2017)
doi:10.1038/s41598-017-03599-8
Received:
22 February 2017
Accepted:
02 May 2017
Published online:
09 June 2017

Abstract
Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by quantitative polymerase chain reaction. Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. This study shows the first association of aberrant telomeres and mtDNA content with suicide completion. Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.

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https://www.nature.com/articles/s41598-017-03599-8

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Reddit user vilnius2013 (PhD in microbiology) summarizes as:
"Many people who commit suicide have genetic abnormalities. Specifically, young people who commit suicide are likelier to have short chromosomal telomeres, while older people who commit suicide tend to have excess mitochondrial DNA."

from r/science

https://www.reddit.com/r/science/comments/6h8u8m/many_people_who_commit_suicide_have_genetic/

[bigheadfred]

People who commit suicide have a short fuse?

[truth_seeker]

This cannot be possible. I have been repeatedly informed that everybody is exactly equal and the same in every way.

Not some smart, some not so. But rather all exactly the same.

As one juror in the OJ case stated: "DNA, so what. Eberybody gots DNA"

Seriously the science of DNA is really cranking up. 

[bigheadfred]

This cannot be possible. I have been repeatedly informed that everybody is exactly equal and the same in every way.

Not some smart, some not so. But rather all exactly the same.

As one juror in the OJ case stated: "DNA, so what. Eberybody gots DNA"

Seriously the science of DNA is really cranking up.

And that is a good thing medically. When they weaponize it, it will be a bad thing.

[truth_seeker]

And that is a good thing medically. When they weaponize it, it will be a bad thing.

My sister, my mother and I have all done various DNA tests. In our cases, what we learned confirmed our old fashioned paper, family tree information.

But at a deeper level, it also confirmed theories of migrations in Europe.

The Irish origin myth about coming from Spain, is likely accurate. During a receding ice age episode people move north from Spain, through France, into the British Isles. Along Europe's western border with the Atlantic.

[bigheadfred]

My sister, my mother and I have all done various DNA tests. In our cases, what we learned confirmed our old fashioned paper, family tree information.

But at a deeper level, it also confirmed theories of migrations in Europe.

The Irish origin myth about coming from Spain, is likely accurate. During a receding ice age episode people move north from Spain, through France, into the British Isles. Along Europe's western border with the Atlantic.

I have been interested in tracking some of our family history like that. Never have done it. I wonder about some Nordic traits, although we are Irish/Scottish for the most part.

[truth_seeker]

@bigheadfred

This page, on this site will be very helpful for your expressed interest

http://www.eupedia.com/genetics/britain_ireland_dna.shtml