Mojo is a drunk and an idiot. He should not be in any president's administration.
What is the West Virginia process for replacing a Senator if he's named? I see you have a Dem Governor, does he make the choice?
If so, I'd bypass Manchin in any Trump cabinet because he will be a reliable crossover Senate vote on every energy and other issue in his quest to be re-elected in '18.
I never mind cherry-picking competent but vulnerable Senators from the other party for an Administration position if there is every confidence you can get someone from your party into the vacated slot.