How likely do you think that is? McConnell has weathered worse and Ryan just got the gig.
Whether it likely or not is not the question, although if Trump wins big, there will be a lot of heat on those who opposed him, like Ryan and McConnell. Boehner went down when a few House conservatives refused support, so if a President refuses support, that speaks pretty loudly.
I consider what the law of the land actually says, not just whether it is likely or not.
There are many confused by this issue. ie - these guys are not elected into leadership positions by their constituents, but by the body they represent.