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Methamphetamine (METH) and related compounds [amphetamine, paramethoxyamphetamine, and methylenedioxymethamphetamine (“ecstasy”)] are addictive substances that can cause serious health problems ranging from acute overdose toxicity and mortality to brain damage with chronic use (Davidson et al., 2001; Kalant, 2001; Rawson et al., 2002). Because METH induces abnormal release of various endogenous transmitters, including glutamate and catecholamines (Stephens and Yamamoto, 1994;Ohmori et al., 1996; Seiden and Sabol, 1996), these substances and some toxic products of their metabolism (i.e., nitric oxide, catechol-quinones, peroxynitrite, and arachidonic acid) are usually considered primary contributors to neural cell damage via oxidative stress (Spina and Cohen, 1989; Lipton and Rosenberg, 1994; Kuhn and Geddes, 2000; Cadet et al., 2001). METH is also known to cause hyperthermia both in humans (Kalant and Kalant, 1975) and rodents .....http://www.jneurosci.org/content/23/9/3924.full