Antidepressant drugs, as well as antipsychotic drugs can have side effects which will effect facial contortions and cause what are called 'facial tics'. One of the most common and well known of these is that antidepressants tend to cause uncontrolled yawning. This has caused many a misunderstanding because it gives family/coworkers/friends a very strong impression that the person is bored with a conversation or meeting, when in reality it is an uncontrollable effect of the drugs.
I think it is clear to anyone watching her behavior on stage that she was behaving in an unnatural and exaggerated way. The most reported anomaly that I have seen reported is her constant need to open both her eyes and her mouth as wide as possible. I will not go deep into the psychological aspects of this behavior except to say that in the wild, easily seen in a hippopotamus or a gorilla, this behavior is fear response to something unexpected which may cause them to feel nervous or threatened in some way. But, it also very easily could be a side effect of a drug she is taking.
Clearly, she does not act or behave like a normal person would in response to more or less normal situations (normal situations for someone in her position doing what she it doing, that is).
The wide-eyed, open-mouth gape, combined with the barely repressed rage and anger that comes across every time she speaks, are all telling signs of some underlying issues.
Unfortunately we will never know what these issues are because she will never ever, under and circumstances possible, ever release her medical records. We can all be assured of that.
But with the full force of the White House covering for her and promoting her candidacy, combined with her sycophantic worshipers in the media, unless she strokes out, on stage, on live TV, they will continue to cover for her any way they can. They will pretend that she as healthy and fit as a 25 year old gymnast, ignoring all the clear evidence that something is wrong.