As long as we aren't wiped out before we can get the technology for reasonable travel outside our solar system (versus 100K years to get somewhere).
I like the idea of genetic bacterial seeding of the universe. Engineer highly resilient bacteria that contains the genetic code of our life (something that could evolve into something like us under the right circumstances- or at least evolve into something), create highly durable space probes that can last millions of years in space, and send them in all directions. Millions of small ones, like the shotgun approach.