Including opponents - even democrats - who were life long residents of that district?
Not sure about life long but long time for sure! The fellow who came closest was a long time resident of the district, was black, and had the wherewithal to self finance a substantial campaign. More recently a white man by the name of John Faulk tired and failed as well.
In 1994, Jackson Lee ran for a seat in the U.S. House of Representatives, challenging four-term incumbent U.S. Congressman Craig Washington of the Houston-based Texas' 18th congressional district in the Democratic primary. Washington had come under fire for opposing several projects that would have benefited the Houston area. Jackson Lee defeated Washington 63%-37%. The victory was tantamount to election in this heavily Democratic, black-majority district. In the general election, she defeated Republican nominee Jerry Burley 73%-24%.
During this time period, Jackson Lee was never challenged in the Democratic primary. In addition, she won re-election with at least 76% of the vote.
See also: United States House of Representatives elections in Texas, 2010#District 18
For the first time in her congressional career, Jackson Lee was challenged in the Democratic primary; her opponents were Houston City Councilmember Jarvis Johnson and Sean Roberts. She defeated them 67%-28%-5%.
It was reported that in October 2010 Jackson Lee was “asking the Department of Justice to investigate whether tea party groups are intimidating black and Hispanic voters in her district.” She requested that Attorney General Eric Holder send poll monitors to make sure that a local group wasn't stopping people from voting.
She won the general election with 70% of the vote, the lowest winning percentage of her career.
In 2012, Jackson Lee was not challenged in the Democratic primary and won the general election with 75% of the vote. http://en.wikipedia.org/wiki/Sheila_Jackson-Lee